Selected Publications

From 2012 to present:

Gd(III)-Pt(IV) theranostic contrast agents for tandem MR imaging and chemotherapy

Casey J Adams,Thomas J. Meade

Chem. Sci.  2020, 11, 2524 - 2530

Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances

Hao Li and Thomas J. Meade

J Am Chem Soc  2019, 43, 17025-17041.

Inhibition of Amyloid-beta Aggregation by Cobalt(III) Schiff Base Complexes: A Computational and Experimental Approach

Aysenur Iscen, Christopher R. Brue, Kaleigh F. Roberts, Joy Kim,

George C. Schatz, and Thomas J. Meade

J Am Chem Soc 2019, 42, 16685-16695.

A water-soluble nanoconjugate for enhanced cellular delivery of receptor-targeted MR contrast agents

Laura K. Moore, Michael Caldwell, Taryn R Townsend, Keith W MacRenaris, Georgette MoyleHeyrman, Nikhil Rammohan,

Erika K Schonher, Joanna E. Burdette, Dean Ho, and Thomas J. Meade

Bioconjug Chem 2019, 30, 2947-2957 .

Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging

Li, H.; Parigi, G.; Luchinat, C.; Meade, T. J.

J Am Chem Soc 2019, 15, 6224-6233.

Effect of Magnetic Coupling on Water Proton Relaxivity in a Series of Transition Metal Gd(III) Complexes.

Lilley, L. M.; Du, K.; Krzyaniak, M. D.; Parigi, G.; Luchinat, C.; Harris, T. D.; Meade, T. J.

Inorg Chem 2018, 57, 5810-5819.

Synthesis and evaluation of MR probes for targeted-reporter imaging.

Verma, K. D.; Massing, J. O.; Kamper, S. G.; Carney, C. E.;

MacRenaris, K. W.; Basilion, J. P.; Meade, T. J.

Chem Sci 2017, 8, 5764-5768.

A multimeric MR-optical contrast agent for multimodal imaging.

Harrison, V. S.; Carney, C. E.; Macrenaris, K. W.; Meade, T. J.

Chem Commun (Camb) 2014, 50, 11469-71.

Progesterone-targeted magnetic resonance imaging probes.

Townsend, T. R.; Moyle-Heyrman, G.; Sukerkar, P. A.; MacRenaris, K. W.;

Burdette, J. E.; Meade, T. J.

Bioconjug Chem 2014, 25, 1428-37.

Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes.

Heffern, M. C.; Velasco, P. T.; Matosziuk, L. M.; Coomes, J. L.; Karras, C.;

Ratner, M. A.; Klein, W. L.; Eckermann, A. L.; Meade, T. J.

Chembiochem 2014, 15, 1584-9.

Gd(III)-labeled peptide nanofibers for reporting on biomaterial localization in vivo.

Preslar, A. T.; Parigi, G.; McClendon, M. T.; Sefick, S. S.; Moyer, T. J.; Haney, C. R.;

Waters, E. A.; MacRenaris, K. W.; Luchinat, C.; Stupp, S. I.; Meade, T. J.

ACS Nano 2014, 8, 7325-32.

Cell labeling via membrane-anchored lipophilic MR contrast agents.

Carney, C. E.; MacRenaris, K. W.; Mastarone, D. J.; Kasjanski, D. R.; Hung, A. H.; Meade, T. J.

Bioconjug Chem 2014, 25, 945-54

Synthesis and characterization of a porphyrazine-Gd(III) MRI contrast agent

and in vivo imaging of a breast cancer xenograft model.

Trivedi, E. R.; Ma, Z.; Waters, E. A.; Macrenaris, K. W.; Subramanian, R.;

Barrett, A. G.; Meade, T. J.; Hoffman, B. M.

Contrast Media Mol Imaging 2014, 9, 313-22.

pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T1 MRI Contrast by Her2-Targeting.

Hong, B. J.; Swindell, E. P.; Macrenaris, K. W.; Hankins, P. L.; Chipre, A. J.;

Mastarone, D. J.; Ahn, R. W.; Meade, T. J.; O'Halloran, T. V.; Nguyen, S. T.

Part Part Syst Charact 2013, 30, 770-774.

Imaging Bacteria with Contrast-Enhanced MR

Adams, CJ., Meade, TJ. 

Met Ions Life Sci (A. Sigel, E. Freisinger and R. Sigel, eds.), 2021. Chapter 15, 425-435.

Magnetic Resonance Theranostics: An Overview of Gadolinium(III)-based Strategies and Magnetic Particle Imaging.

McLeod, SM., Meade, TJ. 

Met Ions Life Sci (A. Sigel, E. Freisinger and R. Sigel, eds.), 2021, Chapter  12, 347-370.

Cobalt(III) Schiff Base complexes stabilize non-fibrillar amyloid-β aggregates with reduced toxicity

Roberts, KF., Brue, CR., Preston, A., Baxter, D., Herzog, E., Varelas, E., Meade, TJ.

J. Inorg. Biochem. 2020, 213, 111265-111275.

Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer

Dong Luo, Andrew Johnson, Xinning Wang, Hao Li, Bernadette O Erokwu,

Sarah Springer, Jason Lou,Gopalakrishnan Ramamurthy, Chris A. Flask,

Clemens Burda, James P. Basilion and Thomas J. Meade

Nano Lett.  2020, 20, 7159-7167.

Maximizing Magnetic Resonance Contrast in Gd(III) Nanoconjugates: Investigation of Proton

Relaxation in Zirconium Metal–Organic Frameworks

Shaunna M McLeod, Lee Robison, Giacomo Parigi, Alyssa Olszewski, Riki J Drout,
Xinyi Gong, Timur Islamoglu, Claudio Luchinat, Omar K. Farha, and Thomas J. Meade

ACS Appl. Mater. Interfaces. 2020, 12, 41157-41166.

Advances in optical and electrochemical techniques for biomedical imaging

Long, YT., Meade, TJ. 

Chem. Sci. 2020,11, 6940-6941

A Ln(III)-3-hydroxypyridine pH responsive probe optimized by DFT

Caldwell, MA., Brue, CR., Whittemore, TJ., Meade, TJ.

RSC Adv 2020, 10, 8994-8999.

A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake.

Casey J Adams, Ruby Krueger, Thomas J. Meade

ACS Chem. Biol. 2020, 15, 334-341.

Self‐Immolative Activation of β‐Galactosidase‐Responsive Probes for In Vivo MR Imaging in Mouse Models

Laura M. Lilley, Sarah Kamper, Michael Caldwell, Zer Keen Chia, David Ballweg, Luke Vistain, Jeffrey Krimmel,

Teresa Anne Mills,  Keith MacRenaris, Paul Lee  Emily, Alexandria Waters, Thomas J. Meade

Angew Chem Int Ed Engl 2019, 132, 396-402.

Cobalt-Schiff base complexes: preclinical research and potential therapeutic uses.

Bajema, EA, Roberts,KF, Meade TJ.  

Met Ions Life Sci (A. Sigel, E. Freisinger and R. Sigel, eds.), 

Guest Editor Peggy L. Carver,

Vol. 19., Chapter 11, 2019, 268-301.

Phase engineering and optical properties of 2D MoSe2: Promise and pitfalls

Eve D. Hanson, Laura M. Lilley, Jeffrey D. Cain, Shiqiang Hao, Edgar Palacios, Koray Aydin,

Chris Wolverton, Thomas Meade, Vinayak P. Dravid

Materials Chemistry and Physics 2019, 225, 219-226.

Calcium-Induced Morphological Transitions in Peptide Amphiphiles Detected by 19F-Magnetic Resonance Imaging.

Preslar, A. T.; Lilley, L. M.; Sato, K.; Zhang, S.; Chia, Z. K.; Stupp, S. I.; Meade, T. J.

ACS Appl Mater Interfaces 2017, 9, 39890-39894.

Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation.

Sleep, E.; Cosgrove, B. D.; McClendon, M. T.; Preslar, A. T.; Chen, C. H.; Sangji, M. H.;

Perez, C. M. R.; Haynes, R. D.; Meade, T. J.; Blau, H. M.; Stupp, S. I.

Proc Natl Acad Sci U S A  2017, 114, E7919-E7928.

Magnetic barcode imaging for contrast agents.

Hung, A. H.; Lilley, L. M.; Hu, F.; Harrison, V. S.; Meade, T. J.

Magn Reson Med 2017, 77, 970-978.

Gd(III)-Gold Nanoconjugates Provide Remarkable Cell Labeling for High Field

Magnetic Resonance Imaging.

Rammohan, N.; Holbrook, R. J.; Rotz, M. W.; MacRenaris, K. W.; Preslar, A. T.;

Carney, C. E.; Reichova, V.; Meade, T. J.

Bioconjug Chem 2017, 28, 153-160.

19F Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures Are Strongly Affected by Their Shape.

Preslar, A. T.; Tantakitti, F.; Park, K.; Zhang, S.; Stupp, S. I.; Meade, T. J.

ACS Nano 2016, 10, 7376-84.

Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents.

Culver, K. S.; Shin, Y. J.; Rotz, M. W.; Meade, T. J.; Hersam, M. C.; Odom, T. W.

J Phys Chem C Nanomater Interfaces 2016, 120, 22103-22109.

Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High Field.

Rammohan, N.; MacRenaris, K. W.; Moore, L. K.; Parigi, G.; Mastarone, D. J.; Manus, L. M.;

Lilley, L. M.; Preslar, A. T.; Waters, E. A.; Filicko, A.; Luchinat, C.; Ho, D.; Meade, T. J.

Nano Lett 2016, 16, 7551-7564.

Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas.

Holbrook, R. J.; Rammohan, N.; Rotz, M. W.; MacRenaris, K. W.; Preslar, A. T.; Meade, T. J.

Nano Lett  2016, 16, 3202–3209.

Cell-Permeable Esterase-Activated Ca(II)-Sensitive MRI Contrast Agent.

MacRenaris, K. W.; Ma, Z.; Krueger, R. L.; Carney, C. E.; Meade, T. J.

Bioconjug Chem 2016, 27, 465-73.

DNA-gadolinium-gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells.

Nicholls, F. J.; Rotz, M. W.; Ghuman, H.; MacRenaris, K. W.; Meade, T. J.; Modo, M.

Biomaterials 2016, 77, 291-306.

Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging.

Vistain, L. F.; Yamamoto, N.; Rathore, R.; Cha, P.; Meade, T. J.

Chembiochem 2015, 16, 2065-72.

Tuning cobalt(III) Schiff base complexes as activated protein inhibitors.

Heffern, M. C.; Reichova, V.; Coomes, J. L.; Harney, A. S.; Bajema, E. A.; Meade, T. J.

Inorg Chem 2015, 54, 9066-74.

Targeted Inhibition of Snail Activity in Breast Cancer Cells by Using a Co(III) -Ebox Conjugate.

Vistain, L. F.; Yamamoto, N.; Rathore, R.; Cha, P.; Meade, T. J.

Chembiochem 2015, 16, 2065-72.

Water-soluble lipophilic MR contrast agents for cell membrane labeling.

Carney, C. E.; MacRenaris, K. W.; Meade, T. J.

J Biol Inorg Chem 2015, 20, 971-7.

Synthesis and Evaluation of Gd(III) -Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen.

Banerjee, S. R.; Ngen, E. J.; Rotz, M. W.; Kakkad, S.; Lisok, A.; Pracitto, R.; Pullambhatla, M.;

Chen, Z.; Shah, T.; Artemov, D.; Meade, T. J.; Bhujwalla, Z. M.; Pomper, M. G.

Angew Chem Int Ed Engl 2015, 54, 10778-82.

Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging.

Harrison, V. S.; Carney, C. E.; MacRenaris, K. W.; Waters, E. A.; Meade, T. J.

J Am Chem Soc 2015, 137, 9108-16.

Theranostic Magnetic Nanostructures (MNS) for Cancer.

Nandwana, V.; De, M.; Chu, S.; Jaiswal, M.; Rotz, M.; Meade, T. J.; Dravid, V. P.

Cancer Treat Res 2015, 166, 51-83.

Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging.

Carney, C. E.; Lenov, I. L.; Baker, C. J.; MacRenaris, K. W.; Eckermann, A. L.;

Sligar, S. G.; Meade, T. J.,

Bioconjug Chem 2015, 26, 899-905.

High relaxivity Gd(III)-DNA gold nanostars: investigation of shape effects on proton relaxation.

Rotz, M. W.; Culver, K. S.; Parigi, G.; MacRenaris, K. W.; Luchinat, C.;

Odom, T. W.; Meade, T. J.

ACS Nano 2015, 9, 3385-96.

Light-activated protein inhibition through photoinduced electron transfer of a ruthenium(II)-cobalt(III) bimetallic complex.

Holbrook, R. J.; Weinberg, D. J.; Peterson, M. D.; Weiss, E. A.; Meade, T. J.

J Am Chem Soc 2015, 137, 3379-85.

Graphene oxide enhances cellular delivery of hydrophilic small molecules by co-incubation.

Hung, A. H.; Holbrook, R. J.; Rotz, M. W.; Glasscock, C. J.; Mansukhani, N. D.;

MacRenaris, K. W.; Manus, L. M.; Duch, M. C.; Dam, K. T.; Hersam, M. C.; Meade, T. J.

ACS Nano 2014, 8, 10168-77

Lanthanide probes for bioresponsive imaging.

Heffern, M. C.; Matosziuk, L. M.; Meade, T. J.

Chem Rev 2014, 114, 4496-539.

Mechanisms of Gadographene-Mediated Proton Spin Relaxation.

Hung, A. H.; Duch, M. C.; Parigi, G.; Rotz, M. W.; Manus, L. M.; Mastarone, D. J.; Dam, K. T.;

Gits, C. C.; Macrenaris, K. W.; Luchinat, C.; Hersam, M. C.; Meade, T. J.

J Phys Chem C Nanomater Interfaces 2013, 117.

High dynamic range processing for magnetic resonance imaging.

Hung, A. H.; Liang, T.; Sukerkar, P. A.; Meade, T. J.

PLoS One 2013, 8, e77883.

Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.

Jensen, S. A.; Day, E. S.; Ko, C. H.; Hurley, L. A.; Luciano, J. P.; Kouri, F. M.; Merkel, T. J.;

Luthi, A. J.; Patel, P. C.; Cutler, J. I.; Daniel, W. L.; Scott, A. W.; Rotz, M. W.; Meade, T. J.;

Giljohann, D. A.; Mirkin, C. A.; Stegh, A. H.

Sci Transl Med 2013, 5, 209ra152.

Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases.

Thorsen, F.; Fite, B.; Mahakian, L. M.; Seo, J. W.; Qin, S.; Harrison, V.; Johnson, S.; Ingham, E.; Caskey, C.; Sundstrom, T.; Meade, T. J.; Harter, P. N.; Skaftnesmo, K. O.; Ferrara, K. W.

J Control Release 2013, 172, 812-22.

Pillar[5]arene as a co-factor in templating rotaxane formation.

Ke, C.; Strutt, N. L.; Li, H.; Hou, X.; Hartlieb, K. J.; McGonigal, P. R.; Ma, Z.; Iehl, J.; Stern, C. L.; Cheng, C.; Zhu, Z.; Vermeulen, N. A.; Meade, T. J.; Botros, Y. Y.; Stoddart, J. F. J Am Chem Soc 2013, 135, 17019-30.

PSA enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness.

Ahrens, M. J.; Bertin, P. A.; Vonesh, E. F.; Meade, T. J.; Catalona, W. J.; Georganopoulou, D. 

Prostate 2013, 73, 1731-7.

Photoinduced electron transfer from PbS quantum dots to cobalt(III) Schiff base complexes: light activation of a protein inhibitor.

Peterson, M. D.; Holbrook, R. J.; Meade, T. J.; Weiss, E. A.

J Am Chem Soc 2013, 135, 13162-7.

Structural optimization of Zn(II)-activated magnetic resonance imaging probes.

Matosziuk, L. M.; Leibowitz, J. H.; Heffern, M. C.; MacRenaris, K. W.; Ratner, M. A.; Meade, T. J.,

Inorg Chem 2013, 52, 12250-61.

High-resolution magnetic resonance imaging of ankle joints in murine arthritis discriminates inflammation and bone destruction in a quantifiable manner.

Rose S, Waters EA, Haney CR, Meade CT, Perlman H.

Arthritis Rheum 2013 65, 2279-89. 

Extending the distance range accessed with continuous wave EPR with Gd3+ spin probes at high magnetic fields.

Edwards, D. T.; Ma, Z.; Meade, T. J.; Goldfarb, D.; Han, S.; Sherwin, M. S.

Phys Chem Chem Phys 2013, 15, 11313-26.

Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.

Matosziuk, L. M.; Harney, A. S.; Macrenaris, K. W.; Meade, T. J.

Eur J Inorg Chem 2012, 2012, 2099-2107.

Rational design of [Co(acacen)L2]+ inhibitors of protein function.

Matosziuk, L. M.; Holbrook, R. J.; Manus, L. M.; Heffern, M. C.; Ratner, M. A.; Meade, T. J.

Dalton Trans 2013, 42, 4002-12.

Axial ligand exchange of N-heterocyclic cobalt(III) Schiff base complexes: molecular structure and NMR solution dynamics.

Manus, L. M.; Holbrook, R. J.; Atesin, T. A.; Heffern, M. C.; Harney, A. S.; Eckermann, A. L.; Meade, T. J.

Inorg Chem 2013, 52, 1069-76.

Cobalt derivatives as promising therapeutic agents.

Heffern, M. C.; Yamamoto, N.; Holbrook, R. J.; Eckermann, A. L.; Meade, T. J.

Curr Opin Chem Biol 2013, 17, 189-96.

A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis.

Rose, S.; Eren, M.; Murphy, S.; Zhang, H.; Thaxton, C. S.; Chowaniec, J.; Waters, E. A.;

Meade, T. J.; Vaughan, D. E.; Perlman, H.

Ann Rheum Dis 2013, 72, 89-95.

Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies.

Velasco, P. T.; Heffern, M. C.; Sebollela, A.; Popova, I. A.; Lacor, P. N.; Lee, K. B.; Sun, X.; Tiano, B. N.;

Viola, K. L.; Eckermann, A. L.; Meade, T. J.; Klein, W. L.

ACS Chem Neurosci 2012, 3, 972-81.

Kinetics and thermodynamics of irreversible inhibition of matrix metalloproteinase 2 by a Co(III) Schiff base complex.

Harney, A. S.; Sole, L. B.; Meade, T. J.

J Biol Inorg Chem 2012, 17, 853-60.

Analytical methods for characterizing magnetic resonance probes.

Manus, L. M.; Strauch, R. C.; Hung, A. H.; Eckermann, A. L.; Meade, T. J.

Anal Chem 2012, 84, 6278-87.

Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate.

Harney, A. S.; Meade, T. J.; LaBonne, C.

PLoS One 2012, 7, e32318.

Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate

Hurtado, R. R.; Harney, A. S.; Heffern, M. C.; Holbrook, R. J.; Holmgren, R. A.; Meade, T. J.  

Mol Pharm 2012, 9, 325-33.

Trinuclear Ruthenium Clusters as Bivalent Electrochemical Probes for Ligand-Receptor Binding Interactions

Feld, D. J.; Hsu, H. T.; Eckermann, A. L.; Meade, T. J. 

Langmuir 2012, 28, 939-49.

For publications prior to 2012, please click here.

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