Selected Publications
From 2012 to present:
Musculoskeletal imaging of senescence
Daldrup-Link, H.E., Suryadevara, V., Tanyildizi, Y., Nernekli, K., Tang, J. -H., Meade, T. J..
Skeletal Radiology 2024
Molecular Engineering of Self-Immolative Bioresponsive MR Probes
Tang, J.-H.; Li, H.; Yuan, C.; Parigi, G.; Luchinat, C.; Meade, T. J..
Journal of the American Chemical Society 2023, 145, 10045-10050.
Engineered Non-Viral Protein Cages Modified for MR Imaging
Kaster, M.; Levasseur, M.; Edwardson, T.; Caldwell, M.; Hofmann, D.; Licciardi, G.; Parigi, G.; Luchinat, C.; Hilvert, D.; Meade, TJ.
ACS Applied Bio Materials, 2023, 6, 2, 591–602.
Molecular Bio-Sensors and the Role of Metal Ions
Edited by Meade, TJ.
ISBN 9781032135786
Published September 27, 2022 by CRC Press.
Dukes, M.; Modo, M.; Meade, TJ.
CRC Press, 2022; pp 261-286.
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Dukes, M.; Meade, TJ.
Biomedicines, 2022, 10, 2376.
Delivery of Targeted Co(III)-DNA Inhibitors of Gli Proteins to Disrupt Hedgehog Signaling
Dukes, M.; Bajema, E.; Whittemore, T.; Holmgren, R.; Meade, TJ.
Bioconjugate Chem., 2022, 33, 643–653.
Functional Disruption of Gli1-DNA Recognition via a Cobalt(III) Complex
Brue, C.; Dukes, M.; Masotti, M.; Holmgren, R.; Meade, TJ.
ChemMedChem, 2022, 17, e2022000.
Li, H., Lou, D., Yuan, C., Wang, X., Wang, J., Basilion, JB., Meade, TJ.
J. Am. Chem. Soc., 2021, 143, 41, 17097-17108 .
Real-Time Tracking of AAV Gene Therapy with Enzyme Activated MR Probes
Taghian, T., Esteves, MG.,Edwards, HG., Meade, TJ.
Molecular Therapy, 2021, 29, 124-134.
Towards Imaging Pt Chemoresistance Using Gd(III)-Pt(II Theranostic MR Contrast Agents
Adams, CJ., Meade, TJ.
ChemMedChem, 2021, 16, 1-10.
Imaging Bacteria with Contrast-Enhanced MR
Adams, CJ., Meade, TJ.
Met Ions Life Sci (A. Sigel, E. Freisinger and R. Sigel, eds.), 2021. Chapter 15, 425-435.
Magnetic Resonance Theranostics: An Overview of Gadolinium(III)-based Strategies and Magnetic Particle Imaging.
McLeod, SM., Meade, TJ.
Met Ions Life Sci (A. Sigel, E. Freisinger and R. Sigel, eds.), 2021, Chapter 12, 347-370.
Cobalt(III) Schiff Base complexes stabilize non-fibrillar amyloid-β aggregates with reduced toxicity
Roberts, KF., Brue, CR., Preston, A., Baxter, D., Herzog, E., Varelas, E., Meade, TJ.
J. Inorg. Biochem. 2020, 213, 111265-111275.
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Targeted Radiosensitizers for MR-Guided Radiation Therapy of Prostate Cancer
Luo, D.; Johnson, A.; Wang, X.; Li, H.; Erokwu, B. O.; Springer, S.; Lou, J.; Ramamurthy, G.;
Flask, C. A.; Burda, C.; Burda, C.; Basilion, J.; and Meade TJ.
Nano Lett. 2020, 20, 7159-7167.
Maximizing Magnetic Resonance Contrast in Gd(III) Nanoconjugates: Investigation of Proton
Relaxation in Zirconium Metal–Organic Frameworks
Mcleod, SM., Robison, L., Parigi, G., Olszewski, A., Drout, RJ., Gong, X., Islamoglu, T.,
Luchinat, C., Farha, OK., and Meade, TJ.
ACS Appl. Mater. Interfaces. 2020, 12, 41157-41166.
Advances in optical and electrochemical techniques for biomedical imaging
Long, YT., Meade, TJ.
Chem. Sci. 2020,11, 6940-6941
A Ln(III)-3-hydroxypyridine pH responsive probe optimized by DFT
Caldwell, MA., Brue, CR., Whittemore, TJ., Meade, TJ.
RSC Adv 2020, 10, 8994-8999.
Gd(III)-Pt(IV) theranostic contrast agents for tandem MR imaging and chemotherapy
Adams, CJ., and Meade, TJ.
Chem. Sci. 2020, 11, 2524 - 2530
A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake.
Adams, CJ., Krueger, R., and Meade, TJ.
ACS Chem. Biol. 2020, 15, 334-341.
Laura M. Lilley, Sarah Kamper, Michael Caldwell, Zer Keen Chia, David Ballweg, Luke Vistain, Jeffrey Krimmel,
Teresa Anne Mills, Keith MacRenaris, Paul Lee Emily, Alexandria Waters, Thomas J. Meade
Angew Chem Int Ed Engl 2019, 132, 396-402.
Cobalt-Schiff base complexes: preclinical research and potential therapeutic uses.
Bajema, EA, Roberts,KF, Meade TJ.
Met Ions Life Sci (A. Sigel, E. Freisinger and R. Sigel, eds.),
Guest Editor Peggy L. Carver,
Vol. 19., Chapter 11, 2019, 268-301.
Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances
Hao Li and Thomas J. Meade
J Am Chem Soc 2019, 43, 17025-17041.
A water-soluble nanoconjugate for enhanced cellular delivery of receptor-targeted MR contrast agents
Laura K. Moore, Michael Caldwell, Taryn R Townsend, Keith W MacRenaris, Georgette MoyleHeyrman, Nikhil Rammohan,
Erika K Schonher, Joanna E. Burdette, Dean Ho, and Thomas J. Meade
Bioconjug Chem 2019, 30, 2947-2957 .
Bimodal Fluorescence-Magnetic Resonance Contrast Agent for Apoptosis Imaging
Li, H.; Parigi, G.; Luchinat, C.; Meade, T. J.
J Am Chem Soc 2019, 15, 6224-6233.
Aysenur Iscen, Christopher R. Brue, Kaleigh F. Roberts, Joy Kim,
George C. Schatz, and Thomas J. Meade
J Am Chem Soc 2019, 42, 16685-16695.
Rotz, M. W.; Holbrook, R. J.; MacRenaris, K. W.; Meade, T. J.
Bioconjug Chem 2018, 29, 3544-3549.
Synthesis and evaluation of MR probes for targeted-reporter imaging.
Verma, K. D.; Massing, J. O.; Kamper, S. G.; Carney, C. E.;
MacRenaris, K. W.; Basilion, J. P.; Meade, T. J.
Chem Sci 2017, 8, 5764-5768.
Lilley, L. M.; Du, K.; Krzyaniak, M. D.; Parigi, G.; Luchinat, C.; Harris, T. D.; Meade, T. J.
Inorg Chem 2018, 57, 5810-5819.
Phase engineering and optical properties of 2D MoSe2: Promise and pitfalls
Eve D. Hanson, Laura M. Lilley, Jeffrey D. Cain, Shiqiang Hao, Edgar Palacios, Koray Aydin,
Chris Wolverton, Thomas Meade, Vinayak P. Dravid
Materials Chemistry and Physics 2019, 225, 219-226.
Preslar, A. T.; Lilley, L. M.; Sato, K.; Zhang, S.; Chia, Z. K.; Stupp, S. I.; Meade, T. J.
ACS Appl Mater Interfaces 2017, 9, 39890-39894.
Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation.
Sleep, E.; Cosgrove, B. D.; McClendon, M. T.; Preslar, A. T.; Chen, C. H.; Sangji, M. H.;
Perez, C. M. R.; Haynes, R. D.; Meade, T. J.; Blau, H. M.; Stupp, S. I.
Proc Natl Acad Sci U S A 2017, 114, E7919-E7928.
Magnetic barcode imaging for contrast agents.
Hung, A. H.; Lilley, L. M.; Hu, F.; Harrison, V. S.; Meade, T. J.
Magn Reson Med 2017, 77, 970-978.
Gd(III)-Gold Nanoconjugates Provide Remarkable Cell Labeling for High Field
Rammohan, N.; Holbrook, R. J.; Rotz, M. W.; MacRenaris, K. W.; Preslar, A. T.;
Carney, C. E.; Reichova, V.; Meade, T. J.
Bioconjug Chem 2017, 28, 153-160.
Preslar, A. T.; Tantakitti, F.; Park, K.; Zhang, S.; Stupp, S. I.; Meade, T. J.
ACS Nano 2016, 10, 7376-84.
Shape-Dependent Relaxivity of Nanoparticle-Based T1 Magnetic Resonance Imaging Contrast Agents.
Culver, K. S.; Shin, Y. J.; Rotz, M. W.; Meade, T. J.; Hersam, M. C.; Odom, T. W.
J Phys Chem C Nanomater Interfaces 2016, 120, 22103-22109.
Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High Field.
Rammohan, N.; MacRenaris, K. W.; Moore, L. K.; Parigi, G.; Mastarone, D. J.; Manus, L. M.;
Lilley, L. M.; Preslar, A. T.; Waters, E. A.; Filicko, A.; Luchinat, C.; Ho, D.; Meade, T. J.
Nano Lett 2016, 16, 7551-7564.
Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas.
Holbrook, R. J.; Rammohan, N.; Rotz, M. W.; MacRenaris, K. W.; Preslar, A. T.; Meade, T. J.
Nano Lett 2016, 16, 3202–3209.
Cell-Permeable Esterase-Activated Ca(II)-Sensitive MRI Contrast Agent.
MacRenaris, K. W.; Ma, Z.; Krueger, R. L.; Carney, C. E.; Meade, T. J.
Bioconjug Chem 2016, 27, 465-73.
DNA-gadolinium-gold nanoparticles for in vivo T1 MR imaging of transplanted human neural stem cells.
Nicholls, F. J.; Rotz, M. W.; Ghuman, H.; MacRenaris, K. W.; Meade, T. J.; Modo, M.
Biomaterials 2016, 77, 291-306.
Vistain, L. F.; Yamamoto, N.; Rathore, R.; Cha, P.; Meade, T. J.
Chembiochem 2015, 16, 2065-72.
Tuning cobalt(III) Schiff base complexes as activated protein inhibitors.
Heffern, M. C.; Reichova, V.; Coomes, J. L.; Harney, A. S.; Bajema, E. A.; Meade, T. J.
Inorg Chem 2015, 54, 9066-74.
Targeted Inhibition of Snail Activity in Breast Cancer Cells by Using a Co(III) -Ebox Conjugate.
Vistain, L. F.; Yamamoto, N.; Rathore, R.; Cha, P.; Meade, T. J.
Chembiochem 2015, 16, 2065-72.
Water-soluble lipophilic MR contrast agents for cell membrane labeling.
Carney, C. E.; MacRenaris, K. W.; Meade, T. J.
J Biol Inorg Chem 2015, 20, 971-7.
Banerjee, S. R.; Ngen, E. J.; Rotz, M. W.; Kakkad, S.; Lisok, A.; Pracitto, R.; Pullambhatla, M.;
Chen, Z.; Shah, T.; Artemov, D.; Meade, T. J.; Bhujwalla, Z. M.; Pomper, M. G.
Angew Chem Int Ed Engl 2015, 54, 10778-82.
Multimeric Near IR-MR Contrast Agent for Multimodal In Vivo Imaging.
Harrison, V. S.; Carney, C. E.; MacRenaris, K. W.; Waters, E. A.; Meade, T. J.
J Am Chem Soc 2015, 137, 9108-16.
Theranostic Magnetic Nanostructures (MNS) for Cancer.
Nandwana, V.; De, M.; Chu, S.; Jaiswal, M.; Rotz, M.; Meade, T. J.; Dravid, V. P.
Cancer Treat Res 2015, 166, 51-83.
Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging.
Carney, C. E.; Lenov, I. L.; Baker, C. J.; MacRenaris, K. W.; Eckermann, A. L.;
Sligar, S. G.; Meade, T. J.,
Bioconjug Chem 2015, 26, 899-905.
High relaxivity Gd(III)-DNA gold nanostars: investigation of shape effects on proton relaxation.
Rotz, M. W.; Culver, K. S.; Parigi, G.; MacRenaris, K. W.; Luchinat, C.;
Odom, T. W.; Meade, T. J.
ACS Nano 2015, 9, 3385-96.
Holbrook, R. J.; Weinberg, D. J.; Peterson, M. D.; Weiss, E. A.; Meade, T. J.
J Am Chem Soc 2015, 137, 3379-85.
Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes.
Heffern, M. C.; Velasco, P. T.; Matosziuk, L. M.; Coomes, J. L.; Karras, C.;
Ratner, M. A.; Klein, W. L.; Eckermann, A. L.; Meade, T. J.
Chembiochem 2014, 15, 1584-9.
Graphene oxide enhances cellular delivery of hydrophilic small molecules by co-incubation.
Hung, A. H.; Holbrook, R. J.; Rotz, M. W.; Glasscock, C. J.; Mansukhani, N. D.;
MacRenaris, K. W.; Manus, L. M.; Duch, M. C.; Dam, K. T.; Hersam, M. C.; Meade, T. J.
ACS Nano 2014, 8, 10168-77
A multimeric MR-optical contrast agent for multimodal imaging.
Harrison, V. S.; Carney, C. E.; Macrenaris, K. W.; Meade, T. J.
Chem Commun (Camb) 2014, 50, 11469-71.
Gd(III)-labeled peptide nanofibers for reporting on biomaterial localization in vivo.
Preslar, A. T.; Parigi, G.; McClendon, M. T.; Sefick, S. S.; Moyer, T. J.; Haney, C. R.;
Waters, E. A.; MacRenaris, K. W.; Luchinat, C.; Stupp, S. I.; Meade, T. J.
ACS Nano 2014, 8, 7325-32.
Cell labeling via membrane-anchored lipophilic MR contrast agents.
Carney, C. E.; MacRenaris, K. W.; Mastarone, D. J.; Kasjanski, D. R.; Hung, A. H.; Meade, T. J.
Bioconjug Chem 2014, 25, 945-54
Synthesis and characterization of a porphyrazine-Gd(III) MRI contrast agent
and in vivo imaging of a breast cancer xenograft model.
Trivedi, E. R.; Ma, Z.; Waters, E. A.; Macrenaris, K. W.; Subramanian, R.;
Barrett, A. G.; Meade, T. J.; Hoffman, B. M.
Contrast Media Mol Imaging 2014, 9, 313-22.
Progesterone-targeted magnetic resonance imaging probes.
Townsend, T. R.; Moyle-Heyrman, G.; Sukerkar, P. A.; MacRenaris, K. W.;
Burdette, J. E.; Meade, T. J.
Bioconjug Chem 2014, 25, 1428-37.
Hong, B. J.; Swindell, E. P.; Macrenaris, K. W.; Hankins, P. L.; Chipre, A. J.;
Mastarone, D. J.; Ahn, R. W.; Meade, T. J.; O'Halloran, T. V.; Nguyen, S. T.
Part Part Syst Charact 2013, 30, 770-774.
Lanthanide probes for bioresponsive imaging.
Heffern, M. C.; Matosziuk, L. M.; Meade, T. J.
Chem Rev 2014, 114, 4496-539.
Mechanisms of Gadographene-Mediated Proton Spin Relaxation.
Hung, A. H.; Duch, M. C.; Parigi, G.; Rotz, M. W.; Manus, L. M.; Mastarone, D. J.; Dam, K. T.;
Gits, C. C.; Macrenaris, K. W.; Luchinat, C.; Hersam, M. C.; Meade, T. J.
J Phys Chem C Nanomater Interfaces 2013, 117.
High dynamic range processing for magnetic resonance imaging.
Hung, A. H.; Liang, T.; Sukerkar, P. A.; Meade, T. J.
PLoS One 2013, 8, e77883.
Spectroscopic elucidation of the inhibitory mechanism of Cys2His2 zinc finger transcription factors
by cobalt(III) Schiff base complexes.
Heffern, M. C.; Kurutz, J. W.; Meade, T. J.
Chemistry 2013, 19, 17043-53.
Crans, D. C.; Meade, T. J.
Inorg Chem 2013, 52, 12181-3.
Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma.
Jensen, S. A.; Day, E. S.; Ko, C. H.; Hurley, L. A.; Luciano, J. P.; Kouri, F. M.; Merkel, T. J.;
Luthi, A. J.; Patel, P. C.; Cutler, J. I.; Daniel, W. L.; Scott, A. W.; Rotz, M. W.; Meade, T. J.;
Giljohann, D. A.; Mirkin, C. A.; Stegh, A. H.
Sci Transl Med 2013, 5, 209ra152.
Pillar[5]arene as a co-factor in templating rotaxane formation.
Ke, C.; Strutt, N. L.; Li, H.; Hou, X.; Hartlieb, K. J.; McGonigal, P. R.; Ma, Z.; Iehl, J.; Stern, C. L.; Cheng, C.; Zhu, Z.; Vermeulen, N. A.; Meade, T. J.; Botros, Y. Y.; Stoddart, J. F. J Am Chem Soc 2013, 135, 17019-30.
PSA enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness.
Ahrens, M. J.; Bertin, P. A.; Vonesh, E. F.; Meade, T. J.; Catalona, W. J.; Georganopoulou, D.
Prostate 2013, 73, 1731-7.
Peterson, M. D.; Holbrook, R. J.; Meade, T. J.; Weiss, E. A.
J Am Chem Soc 2013, 135, 13162-7.
Structural optimization of Zn(II)-activated magnetic resonance imaging probes.
Matosziuk, L. M.; Leibowitz, J. H.; Heffern, M. C.; MacRenaris, K. W.; Ratner, M. A.; Meade, T. J.,
Inorg Chem 2013, 52, 12250-61.
Rose S, Waters EA, Haney CR, Meade CT, Perlman H.
Arthritis Rheum 2013 65, 2279-89.
Edwards, D. T.; Ma, Z.; Meade, T. J.; Goldfarb, D.; Han, S.; Sherwin, M. S.
Phys Chem Chem Phys 2013, 15, 11313-26.
Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.
Matosziuk, L. M.; Harney, A. S.; Macrenaris, K. W.; Meade, T. J.
Eur J Inorg Chem 2012, 2012, 2099-2107.
Rational design of [Co(acacen)L2]+ inhibitors of protein function.
Matosziuk, L. M.; Holbrook, R. J.; Manus, L. M.; Heffern, M. C.; Ratner, M. A.; Meade, T. J.
Dalton Trans 2013, 42, 4002-12.
Manus, L. M.; Holbrook, R. J.; Atesin, T. A.; Heffern, M. C.; Harney, A. S.; Eckermann, A. L.; Meade, T. J.
Inorg Chem 2013, 52, 1069-76.
Cobalt derivatives as promising therapeutic agents.
Heffern, M. C.; Yamamoto, N.; Holbrook, R. J.; Eckermann, A. L.; Meade, T. J.
Curr Opin Chem Biol 2013, 17, 189-96.
A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis.
Rose, S.; Eren, M.; Murphy, S.; Zhang, H.; Thaxton, C. S.; Chowaniec, J.; Waters, E. A.;
Meade, T. J.; Vaughan, D. E.; Perlman, H.
Ann Rheum Dis 2013, 72, 89-95.
Velasco, P. T.; Heffern, M. C.; Sebollela, A.; Popova, I. A.; Lacor, P. N.; Lee, K. B.; Sun, X.; Tiano, B. N.;
Viola, K. L.; Eckermann, A. L.; Meade, T. J.; Klein, W. L.
ACS Chem Neurosci 2012, 3, 972-81.
Harney, A. S.; Sole, L. B.; Meade, T. J.
J Biol Inorg Chem 2012, 17, 853-60.
Analytical methods for characterizing magnetic resonance probes.
Manus, L. M.; Strauch, R. C.; Hung, A. H.; Eckermann, A. L.; Meade, T. J.
Anal Chem 2012, 84, 6278-87.
Targeted inactivation of Snail family EMT regulatory factors by a Co(III)-Ebox conjugate.
Harney, A. S.; Meade, T. J.; LaBonne, C.
PLoS One 2012, 7, e32318.
Specific inhibition of the transcription factor Ci by a cobalt(III) Schiff base-DNA conjugate
Hurtado, R. R.; Harney, A. S.; Heffern, M. C.; Holbrook, R. J.; Holmgren, R. A.; Meade, T. J.
Mol Pharm 2012, 9, 325-33.
Feld, D. J.; Hsu, H. T.; Eckermann, A. L.; Meade, T. J.
Langmuir 2012, 28, 939-49.